• Latest
  • Trending
  • All
Unique high-throughput approach improves the design of new protein structures

Unique high-throughput approach improves the design of new protein structures

October 29, 2022
Data Integration Technologies

Unleashing the Potential of Data Integration Technologies: Seamless Data Flow

June 3, 2023
5 best advantage of real time data integration

5 best advantage of real time data integration

May 30, 2023
Demystifying Data Integration Challenges

Demystifying Data Integration Challenges: Strategies for Success

May 29, 2023
Data Integration Hub

The Dynamic Data Integration Hub: Unlocking Data’s Full Potential

May 29, 2023
Integrated data warehouse

Optimize Data Management with an Integrated Data Warehouse Platform 2023

May 29, 2023
Data Science Bootcamp for Beginners

Data Science Bootcamp for Beginners: Learn the Essentials of Big Data Analytics

April 25, 2023
Tips for Finding Affordable Workers Compensation Insurance Companies

Tips for Finding Affordable Workers Compensation Insurance Companies

April 21, 2023
Gartner Magic Quadrant for Data Integration Tools

Gartner Magic Quadrant for Data Integration Tools: Everything You Need To Know

March 22, 2023
Salesforce Data Integration

What is Salesforce Data Integration? Top Benefits and Best Practices

March 13, 2023
Oracle Analytics Cloud Backup: Keep Your Data Safe and Secure

Oracle Analytics Cloud Backup: Keep Your Data Safe and Secure

January 7, 2023
Veeam Backup Cloud Server - The Best for Enterprises

Veeam Backup Cloud Server – The Best for Enterprises

December 31, 2022
Domo marketing analytics

The Domo Marketing Analytics Review: The Most Comprehensive and Powerful Tool Available for Email Marketing

December 30, 2022
Saturday, June 3, 2023
  • Login
Infodoc.info
  • Home
  • Astronomy & Space
  • Biology
  • Chemistry
  • DTC
  • Marketing
  • Technology
  • Stories
    • Guides
    • How Tos
    • Apple
No Result
View All Result
  • Home
  • Astronomy & Space
  • Biology
  • Chemistry
  • DTC
  • Marketing
  • Technology
  • Stories
    • Guides
    • How Tos
    • Apple
No Result
View All Result
Infodoc.info
No Result
View All Result

Unique high-throughput approach improves the design of new protein structures

by Megusta
October 29, 2022
in Biology
0
Unique high-throughput approach improves the design of new protein structures

protein folding
Credit: Unsplash/CC0 Public Domain

Northwestern Medicine investigators have solved a challenging protein design puzzle using a unique high-throughput approach, according to a study published in Proceedings of the National Academy of Sciences.

The approach could enhance the development of new therapeutics and biotechnology tools, according to Gabriel Rocklin, Ph.D., assistant professor of Pharmacology and senior author of the study.

“The lessons from designing ɑββɑ proteins are important for any computational protein design effort, including designing new therapeutics,” said Rocklin, who is also a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Protein folding is an essential cellular process that enables proteins to function properly and avoid contributing to disease. One major challenge in computationally designing new protein structures in a laboratory is that most designed proteins are unable to fold into their designed structures when tested.

In previous work, Rocklin’s team identified the ɑββɑ fold is unusually challenging to design despite its simple structure, with the best designs having just a two percent success rate. To resolve this issue, Rocklin’s team tested thousands of new ɑββɑ designs and used machine learning methods to examine the properties of stable and unstable designs.

“ɑββɑ proteins have a very simple fold that looks like the letter ‘M’. This structure is much simpler than most naturally occurring proteins, which makes it a good testing ground that we can use to understand and improve protein design,” Rocklin said.

In the current study, the investigators designed over 10,000 new ɑββɑ proteins and by using specialized high-throughput experiments discovered that more than one-third of them folded into stable structures. The investigators were also able to identify the biophysical properties that stabilize ɑββɑ proteins as well as compare different protein design methods, according to Rocklin.

See also  Synthetic energy metabolism enables twin engine for cell
Powered by Inline Related Posts

“By making changes to our design protocol, we increased our design success rate from two percent to above 30 percent. This clarified better ways to design ɑββɑ proteins and also helped us understand what makes them stable or unstable,” Rocklin said.

The current approach is applicable for any computational protein design effort. Additionally, ɑββɑ proteins also have the potential to be developed into therapeutics by modifying their surfaces so they can bind to therapeutic targets, according to Rocklin.

“These proteins can become even more stable by connecting the two ends of the ‘M’ together to form a loop, which could be an exciting strategy for designing therapeutics,” Rocklin added.

Megusta

Megusta

No Result
View All Result

Categories

  • Apple
  • Astronomy & Space
  • Biology
  • Chemistry
  • Data
  • DTC
  • Guides
  • How Tos
  • Marketing
  • Technology
Infodoc.info

Copyright © 2022 Infodoc.info. All right reserved.

Navigate Site

  • About Us
  • Contact
  • Disclaimers
  • Privacy Policy
  • Terms and Conditons

Follow Us

No Result
View All Result
  • Home
  • Astronomy & Space
  • Biology
  • Chemistry
  • DTC
  • Marketing
  • Technology
  • Stories
    • Guides
    • How Tos
    • Apple

Copyright © 2022 Infodoc.info. All right reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In